This is the best lecture I've ever had, given by a professor I've never met. Carnegie Mellon University professor, Randy Pausch, is dying of pancreatic cancer at 47. CMU has a tradition called "Last lecture" - every year, a professor gives the lecture they would give if they were dying. This year, they renamed it "Journeys". As Randy said, "Damn, I finally nail the venue and they rename it."
It's 85 minutes long, so be sure to have the time to watch it in a single sitting. I've chosen this version because it has the introduction by his friend, Steve, but the download at Blip seems to have better sound. Your choice.
Trust me, if it were between this and "Spooks", Randy would win, hands down.